They induced thrombosis in mice using FeCl3, which results in the formation free radicals followed by vascular endothelium injury. initiated by contact activation of factor XII (FXII), which consequently activates plasma factor XI (FXI). Activated FXI (FXIa) then triggers factor … Continue reading They induced thrombosis in mice using FeCl3, which results in the formation free radicals followed by vascular endothelium injury